Blake Howard got the Spruce Kings on the board early in the first period on an unassisted goal at 4:58.
AJ Vanderbeck and Lucas Sowder responded for Wenatchee before the period was out. Vanderbeck added another in the second as Wenatchee opened up a 3-1 lead going in the third.
Howard got his second of the game at 6:08 of the third to get the Spruce Kings back in the game.
Jasper Weatherly sealed for the Wild with an empty-net goal with 44 seconds left in the third.
The two teams resume the series Monday night in Prince George. Game time is 7 p.m.